"This Week" co-anchor Jonathan Karl sits down with House Speaker Emerita Rep. Nancy Pelosi for a conversation about her nearly four-decade career in Washington as she prepares to leave office.

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Venezuelan President Nicolas Maduro and his wife, Cilia Flores, were captured overnight from their home in Caracas during a U.S. military operation.

Winter storm pushing across the country ahead of New Year's Eve; new CDC report shows flu cases soaring nationwide; reports suggest CIA drone strike was behind attack on Venezuela port facility.