Teclistamab, a T-cell engager targeting B-cell maturation antigen, showed promise as a rescue therapy in 10 patients with refractory autoimmune diseases and led to clinical and serologic improvemen ...

To the Editor: In their article on the Community-Acquired Pneumonia: Evaluation of Corticosteroids (CAPE COD) trial, Dequin et al. (May 25 issue) 1 report an almost 50% lower 28-day mortality in the ...

Abstract The morbidity and mortality that are associated with hepatitis B virus (HBV) infection have been overshadowed by the public health prominence of other infectious diseases, including human ...

There is sexism in medicine, but there may also be a more insidious obstacle. I’ve been haunted at every step of my career by the fear that I am a fraud. And not only do we women tend to perseverate ...

Malaria is a mosquito-borne parasitic disease. In sub-Saharan Africa, the vast majority of cases are caused by Plasmodium falciparum infection in young children. In this region in 2020, there were an ...

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi ...

Methods We randomly assigned patients with type 2 diabetes and chronic kidney disease (defined by an estimated glomerular filtration rate [eGFR] of 50 to 75 ml per minute per 1.73 m 2 of body-surface ...

Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an adjunct to lifestyle ...

Background Trastuzumab deruxtecan has shown efficacy in patients with previously treated human epidermal growth factor receptor 2 (HER2)–positive advanced or metastatic breast cancer. The efficacy and ...

Methods In a phase 3, double-blind trial, we randomly assigned patients with bronchiectasis (in a 1:1:1 ratio for adults and a 2:2:1 ratio for adolescents) to receive brensocatib (10 mg or 25 mg once ...